Structure-based redesign of proteins for minimal T-cell epitope content
نویسندگان
چکیده
منابع مشابه
B and T-Cell Epitope Prediction of the OMP25 Antigen for Developing Brucella melitensis Vaccines for Sheep
Brucellosis, produced by Brucella species, is a disease that causes severe economic losses for livestock farms worldwide Due to serious economic and medical consequences of this disease, many efforts have been made to prevent the infection through the use of recombinant vaccines based on Brucella outer membrane protein (OMP) antigens. In the present study, a wide range of on-line prediction sof...
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در سالهای اخیر،اختلالات کیفیت توان مهمترین موضوع می باشد که محققان زیادی را برای پیدا کردن راه حلی برای حل آن علاقه مند ساخته است.امروزه کیفیت توان در سیستم قدرت برای مراکز صنعتی،تجاری وکاربردهای بیمارستانی مسئله مهمی می باشد.مشکل ولتاژمثل شرایط افت ولتاژواضافه جریان ناشی از اتصال کوتاه مدار یا وقوع خطا در سیستم بیشتر مورد توجه می باشد. برای مطالعه افت ولتاژ واضافه جریان،محققان زیادی کار کرده ...
15 صفحه اولComputational structure-based redesign of enzyme activity.
We report a computational, structure-based redesign of the phenylalanine adenylation domain of the nonribosomal peptide synthetase enzyme gramicidin S synthetase A (GrsA-PheA) for a set of noncognate substrates for which the wild-type enzyme has little or virtually no specificity. Experimental validation of a set of top-ranked computationally predicted enzyme mutants shows significant improveme...
متن کاملSupporting Information for “Computational Structure-Based Redesign of Enzyme Activity”
Sec. S1 describes in more detail the protein redesign algorithms and the computational protocol, including computational experiment design and supporting data, used to redesign GrsA-PheA. Sec. S2 gives details about the structural analysis of the predicted mutants (Sec. S2.1) and the comparison to other methods and evolution (Sec. S2.2). Sec. S3 gives additional details about the experimental p...
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ژورنال
عنوان ژورنال: Journal of Computational Chemistry
سال: 2013
ISSN: 0192-8651
DOI: 10.1002/jcc.23213